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MingCelerKnock-In
Knock-in
Knock-in mice (KI) are genetically engineered models in which an exogenous functional gene is precisely inserted into a specific genomic locus via homologous recombination, enabling stable and persistent expression within cells. Mingxun Biotech employs the TurboMice? tetraploid complementation technique to efficiently generate knock-in mice.
MingCeler Biotech offers customized precision Rosa26 KI and H11 KI mouse models—both recognized as "safe harbor" sites. These ensure stable, widespread, and predictable expression of the inserted gene across various tissues, without compromising the health of the mice. Using our advanced platform, homozygous KI mice can be generated directly from engineered cells in a single step, with a model development cycle as short as three months, significantly accelerating your research progress.
TurboMice? Deliverables
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Strategy design1-2 days
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Molecular vector construction2-4 weeks
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Cell editing and screening4-6 weeks
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Tetraploid mouse production4-6 weeks
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Weaning and transportation3 weeks
Achieve target homozygous
Gene knock-in mouse turnaround time
Gene knock-in mouse turnaround time
Only 3-5 months
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Customized Genetic Models with Guaranteed Homozygosity—No Breeding Required
Guarantee
Mingceler provides the industry's most robust guarantee: successful generation of genetically engineered mice. Should we fail to deliver animals with the specified genotype, the client’s service fee will be fully refunded*.
*Exclusions apply for genetic modifications that severely compromise viability, morbidity, or fertility due to intrinsic biological constraints.
Online Quotation
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We offer tailored gene editing solutions—get a free quote instantly.
Fill out the form, and we will contact you within two business days.
Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).
Fill out the form, and we will contact you within two business days.
Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).
